“All of the things to everyone everywhere”: A mixed methods analysis of community perspectives on equitable access to monoclonal antibody treatment for COVID-19

Background Neutralizing monoclonal antibody (mAb) treatment for COVID-19 prevents hospitalization and death but is underused, especially in racial/ethnic minority and rural populations. Reasons for underuse and inequity may include community member lack of awareness or healthcare access barriers, among others. This study assessed mAbs community awareness and opportunities for improving equitable mAb access. Methods A concurrent mixed methods study including surveys and focus groups with adults with high-risk conditions or their proxy decision-makers. Surveys and focus group guides addressed diffusion of innovation theory factors. Descriptive statistics and Fisher’s exact method was used to report and compare survey findings by race and ethnicity. Rapid qualitative methods were used for focus group analysis. Results Surveys from 515 individuals (460 English, 54 Spanish, 1 Amharic), and 8 focus groups (6 English, 2 Spanish) with 69 participants, completed June 2021 to January 2022. Most survey respondents (75%) had heard little or nothing about mAbs, but 95% would consider getting mAb treatment. Hispanic/Latino and Non-Hispanic People of Color (POC) reported less awareness, greater concern about intravenous infusions, and less trust in mAb safety and effectiveness than White, Non-Hispanic respondents. Focus group themes included little awareness but high interest in mAb treatment and concerns about cost and access barriers such as lacking established sources of care and travel from rural communities. Focus groups revealed preferences for broad-reaching but tailored messaging strategies using multiple media and trusted community leaders. Conclusions Despite unfamiliarity with mAb treatment, most respondents were open to receiving mAbs or recommending mAbs to others. While mAb messaging should have broad reach “to everyone everywhere,” racial and geographic disparities in awareness and trust about mAbs underscore need for tailored messaging to promote equitable access. Care processes should address patient-level barriers like transportation, insurance, or primary care access. COVID-19 treatment dissemination strategies should promote health equity.

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Introduction
For the first year of the COVID-19 global pandemic, little could be done to effectively prevent or treat the disease beyond behavioral measures (e.g., social distancing) and symptom management.
The introduction of neutralizing monoclonal antibody (mAb) treatments represented the first significant evidence-based advancement in outpatient treatment for COVID-19. The first mAb for COVID-19 (bamlanivimab) was authorized for emergency use in the United States in November 2020 to treat symptomatic COVID-19 among high-risk outpatient populations [1][2][3].
Additional mAbs were introduced thereafter, and availability and use fluctuated as different mAbs were determined to be more or less effective for different variants [1]. However, despite evidence of effectiveness, a strong recommendation from the National Institutes of Health (NIH), and medication provided free of cost to the patient, widespread use lagged availability and disparities in access and use were observed [4,5]. Even now, as COVID-19 is increasingly seen as an endemic condition we must learn to manage [6], there remains a need to ensure timely access to treatment, particularly among racial/ethnic minorities with a disproportionate burden of disease [4,5]. This paper presents a mixed methods analysis of community perspectives on equitable access to mAbs.
As with most health care innovations, there are multiple potential factors at the level of individual patients, families, communities, health care and public health systems, and the media that likely influenced uptake of mAbs for treatment of COVID-19 [7]. Presumably central is general community and health care provider awareness of the existence of evidence-based treatment for COVID-19 among those not yet sick enough to be hospitalized. Implementation factors for accessing care are likely also important. Originally, eligibility was restricted to adults and adolescents with a complex set of criteria indicating a high-risk of poor outcomes for COVID-19 [8]. Initially, treatment required a one-hour intravenous (IV) infusion delivered in a clinical setting with personnel qualified to monitor for adverse reactions [9]. The complex eligibility criteria and IV delivery of treatment requiring care in a well-staffed clinical facility may have contributed to slow uptake and demographic disparities in use [10].
People with symptoms of COVID-19 must be tested, diagnosed, receive a referral for treatment from a medical provider, secure and attend an appointment all within 10 days of first experiencing symptoms and without worsening to the point of requiring hospitalization to receive mAbs. These steps require timely action on the part of people experiencing symptoms of COVID-19 to get tested as well as knowledgeable, prepared health care providers, willing patients, and systems set up to deliver treatment efficiently. Over the course of 2021, eligibility criteria were expanded and simplified, an option for subcutaneous injection was introduced [11], and several states implemented policies designed to facilitate access (e.g., standing orders, selfreferral, mobile treatment sites) [12][13][14][15][16]. For instance, the state of Colorado set up a secure webbased system was set up in concert with the state health department to enable community health care providers to refer patients for mAb treatment at one of the multiple infusion sites across the state. Despite efforts to improve access and streamline processes, the multi-step process for accessing treatmentincluding requiring assessing of eligibility and a referral from a medical provider -may be a deterrent for patients and providers alike and a potential source of disparities in access and use of mAb treatmentespecially in rural areas and populations with lower rates of insurance coverage [17].
A large-scale analysis of racial and ethnic disparities in access to mAb treatment for COVID-19 using patient electronic health record data from 41 U.S. health care systems was conducted by the PCORNet in 2021 [5]. Their analysis found that less than 2% of over 700,000 eligible mAb patients between November 2020 (when mAbs were authorized) and August 2021 received the treatment. Monthly mAb treatment rates increased over time, from less than 1% in November 2020 to approximately 6% in August 2021. Of those who received mAbs, racial/ethnic minority groups were underrepresented, with disparate access for Black, Asian, and Hispanic patients [5].
Thus, concerns about the inequitable access to and use of mAbs among marginalized patients with COVID-19 appear legitimate and observable nationally. To address these disparities in COVID-19 outcomes, understanding the factors influencing inequitable access to and treatment use is critical. For instance, it is unclear to what extent mAb treatment access disparities are due to community-level knowledge, cultural, or psychosocial factors (e.g., lack of awareness, trust in treatment) versus logistical factors (e.g., access to care, cost).
This study assessed community awareness and opportunities for improving equitable access to and use of mAbs in Colorado. We used concurrent quantitative and qualitative methods (surveys and focus groups) to understand the perspectives of community members in Colorado who might be eligible to receive mAb treatment if diagnosed with COVID-19 or who were proxy decision makers for those who might qualify for mAb treatment. We used a concurrent mixed methods approach [18], which uses triangulation of quantitative and qualitative findings to gain a deeper understanding and identify consistent/inconsistent themes among surveys and focus groups.
Study findings informed mAb treatment messaging, packaging, and distribution of materials to community members and health care providers. Findings also were shared with Colorado policymakers to identify strategies for improving equitable access to and use of mAb treatment.

Study Design and Setting
This study used a concurrent mixed methods design to assess community awareness, trust, willingness to receive treatment, and opportunities for community messaging about mAb treatment for COVID-19 in the U.S. state of Colorado. The study was conducted from June 2021-January 2022. Rogers' diffusion of innovations theory was used to guide the design of a community survey and a focus group guide [19]. Results then informed the design of community-level dissemination strategies for treatments for COVID-19. A parallel component of the project assessed health care provider perspectives, and informed a provider-level dissemination strategy, reported elsewhere [20].

Participants and Recruitment
Eligibility criteria for surveys included adults at least 18 years of age living in Colorado who self-identified as high risk for poor outcomes from COVID-19 or as a proxy decision maker for someone at high risk. We aimed to recruit 450 people to participate in surveys and between 60 and 80 people to participate in 8 focus groups (6 English, 2 Spanish, 8-10 people each). To address geographic and racial/ethnic disparities in access to care and COVID-19 outcomes, we sought to overrepresent respondents who identified as Hispanic/Latino relative to state demographics and those from rural areas. The survey was made available in 7 languages, Potential focus group participants were a convenience sample identified from 373 survey respondents who had indicated they agreed to further contact regarding related research studies during survey completion. Survey participants who agreed to further contact were stratified by the language of survey completion (English, Spanish). English-language survey participants were then further stratified using the ZIP code they provided on the survey as living in an urban/suburban or rural region of the state. Based on the preferred method of contact listed in the survey, participants in three strata (English-Urban/Suburban, English-Rural, Spanish) were contacted to participate in a focus group. Potential participants were emailed in batches of 20 or texted in batches of 10. Potential participants were contacted up 3 times before no further contact was made. Participants who responded to participation requests selected an available focus group time. Of those willing to be contacted, 258 people (69.2%) did not respond to contact or declined participation in focus groups. This method of focus group recruitment did not yield a sufficient number of Spanish-speakers to conduct a planned second Spanish-language focus group. We worked with a community-based organization to identify additional participants from the Hispanic/Latino community. Staff from the community-based organization recruited additional participants from clients served by their organization to complete the survey and participate in a focus group.

Survey Measures and Data Collection
The survey included 4 screening items, 18 items assessing demographics and health status, 15 items assessing awareness and experiences with COVID-19 tests, vaccines, and treatments, and 23 items about trust and willingness to receive mAb treatment (16 items about receiving treatment oneself, and 7 items about accepting/recommending treatment as a proxy decision maker). The survey items were developed specifically for this study. We tested an original survey draft for general flow, length, and understandability with 6 community members and subsequently revised the survey. See S1 Appendix for the final survey. The survey was administered electronically using REDCap electronic data capture tools hosted at the University of Colorado [22]. Participants with valid responses received a $25 e-gift card.
To identify potentially invalid responses [23], which were common due to the public availability of the survey link, we reviewed responses for missing answers and logic checks. Survey responses were downloaded weekly and reviewed in Excel, using conditional formatting to identify red flags such as missing or duplicate addresses, repeat free text responses in large clusters, duplicate names, and ZIP codes outside of Colorado. We also scanned responses for patterns in names, and email addresses. Logic checks were also done within survey items (i.e., if a respondent said they had never been tested for COVID-19 but had received a positive test for COVID-19; or if a respondent said they had never had COVID-19 but had received monoclonal antibody treatment for COVID -19). Finally, we conducted an internet search for each address to confirm it was a legitimate residential address in Colorado. We confirmed residence at that address through internet searches for any responses that raised the above red flags.

Focus Group Data Collection
Focus group discussion guide topics include knowledge about mAbs, questions or concerns about mAb treatment, whether they would consider this treatment, perceptions on the process of obtaining treatment, and potential methods to inform members of their community about mAb treatment. The focus group guide can be found in S2 Appendix. All focus groups were conducted virtually using the Zoom virtual meeting platform. Each focus group was moderated by one of two study investigators with more than 10 years of training and experience in qualitative research and a research staff member with 7 years of experience in qualitative research (CG). CG completed focus group recruitment. Both investigators identify as a woman (BK (PhD) and LRD (MD; bilingual in English and Spanish)). The research staff member is a woman who is bilingual English/Spanish. Focus groups lasted between 60-90 minutes, and participants were remunerated $100 for their participation. No other people besides participants and moderators attended focus groups. The focus groups began with brief introductions by the moderators and participants who did not know each other before the focus group. During introductions, moderators and participants shared their pronouns, location, hobbies/interests and responded to an icebreaker question (e.g., What is your favorite movie). After introductions, there was an initial inquiry into mAbs knowledge. Then participants were shown a brief Combat Covid video [24] about mAbs for COVID-19, and the moderator reviewed a flyer created by the mAb Colorado team that provided information on the process of obtaining mAbs treatment in Colorado (both videos and flyers are available in English and Spanish) [25]. These resources were used during focus groups based on the survey findings of limited knowledge of mAbs so that focus group participants could provide their views with more baseline knowledge about the treatment and how to obtain it. Focus groups were recorded using the Zoom platform and transcribed/translated by a commercial transcription company. Any identifying information was removed from transcripts. Transcripts were not returned to participants for comment or correction.

Quantitative Analysis
We used chi-square and Fisher's exact tests for categorical variables and t-tests for continuous variables to compare demographic information, awareness and experience with COVID-19 tests, vaccines and treatments, and trust in monoclonal antibody treatment between participants who self-reported as White Non-Hispanic, Hispanic/Latino (any race), or other Non-Hispanic People of Color (POC). Using chi-square and Fisher's exact tests for categorical variables and t-tests for continuous variables, we compared demographic information between participants who completed the focus group to those that did not. We performed sub-analyses to compare responses among Hispanic participants by the language of survey completion (Spanish vs. English). We created a bar plot to show all respondents' awareness of COVID-19 tests, vaccines, and treatments.

Qualitative Analysis
Focus group transcripts were analyzed using rapid qualitative methods [26] based on predefined areas of interest to inform the dissemination of mAbs by one investigator who moderated the focus groups (LRD) and the research staff member who co-moderated (CG). Field notes made during the focus groups were reviewed before analysis in conjunction with a review of transcripts to confirm data saturation. However, they were not analyzed or used to draw conclusions as it was determined they offered no additional relevant information to inform analytic conclusions. Transcripts were summarized in a table in Microsoft Word by research staff members with rows corresponding to focus group discussion topics (e.g., Baseline knowledge about monoclonal antibodies, Willingness to receive mAb treatment). Differences across summaries were resolved through consensus. Using matrix analysis techniques [27], summaries were categorized into English-Urban/Suburban, English-Rural, and Spanish. There were insufficient numbers of Spanish-speaking focus group participants to permit similar distinctions for geographic location. The two research team members identified and grouped key themes from summaries. They then compared themes across the focus group types using a saturation grid [28], which visually aligns support for themes across focus group types to cross-check and confirm evidence of themes against the focus group data. We did not complete member-checking with participants, but findings were shared with the project's community stakeholder advisory panel, who endorsed findings that reflected community member experiences and viewpoints.

Sample Characteristics
A total of 515 participants completed the survey; 54 completed it in Spanish, 460 in English, and one in Amharic. Sixty-nine survey respondents participated in a subsequent focus group, with a total of 6 focus groups conducted. Table 1 shows sample characteristics for survey and focus group participants. Survey respondents were predominantly women, employed, with a wide range of educational backgrounds, and from various racial/ethnic groups. Racial/ethnic minorities were overrepresented relative to the Colorado population, with a greater proportion of Hispanic respondents than US census data for Colorado (27.4% survey vs 21.8% census), more Black/African American (6.8% survey vs 4.6% census), more mixed race (5.4% survey vs 3.1% census), and fewer White Non-Hispanic (54.9% survey vs 67.7% census). About 89.5% of survey respondents indicated that they lived in a metropolitan area, while 8.5% resided in a micropolitan, small town or rural area; respondents spanned 30 of the 64 counties in the state.
About 60% of respondents indicated they had at least one condition that put them at high risk for poor outcomes for COVID-19 (and thus would be eligible for mAbs). About a third of participants reported they had confirmed or suspected COVID-19, and 4.8% of those indicated they were hospitalized for COVID-19. Compared with survey participants that did not participate in a focus group, focus group participants were somewhat older and had higher levels of education. There were no other statistically significant differences in demographics between focus group and non-focus group participants.

Quantitative Results
As shown in Table 2 and Figure 1 Table 3 shows trust in monoclonal antibody treatment for COVID-19 overall and by racial/ethnic group for a variety of potential concerns (safety, efficacy, side effects, i.e., 'won't make someone sick', availability, affordability). A substantial proportion of respondents (~35-45%) indicated they didn't know enough to tell if they would trust mAbs or not. Among respondents who indicated some level of trust, the majority said they trusted at least somewhat that mAbs were safe and effective; trust was somewhat lower in availability and affordability. There were significant differences in trust in mAb safety and efficacy among racial/ethnic groups: White Non-Hispanic survey respondents were consistently highest in trust in safety, keeping someone out of the hospital, and not making someone sick (i.e., side effects). There were no significant racial/ethnic differences for mAb availability or affordability and no differences in trust between Hispanic/Latino English-vs Spanish-language survey respondents.  Table 4 shows willingness to receive mAbs oneself (among 391 respondents with at least one high-risk condition) and to recommend mAbs for a friend, family member, or another person as a proxy decision maker. Nearly 40% of respondents with 1+ high-risk condition indicated they were very worried about being hospitalized if they were to be diagnosed with COVID-19; Hispanic/Latino respondents indicated being much more worried about hospitalization (57.0%) than White Non-Hispanic (31.1%) and Other racial/ethnic groups (35.0%) respondents. Nearly all (97.7% yes/maybe) respondents reported they would consider getting mAb treatment if diagnosed with COVID-19 if it were recommended by a doctor; there were no significant differences in willingness to accept mAb treatment across racial/ethnic groups. Upon learning mAbs were delivered by IV infusion (note the survey was designed and launched before availability of subcutaneous injection options), about 16% indicated they were less willing to get the treatment; Hispanic/Latino and Non-Hispanic POC respondents were significantly less inclined to accept mAb treatment through IV infusion relative to White Non-Hispanic respondents. Respondents were generally willing to receive mAb treatment in a hospital (95.5% yes/maybe) or a specialty care center (93.8% yes/maybe); there was greater hesitation about receiving treatment in a mobile care unit (71.2% yes/maybe). There were significant racial/ethnic differences in willingness to receive mAb treatment across the various settings; while trends were similar to the overall findings, White Non-Hispanic respondents were generally less hesitant about getting treatment in any given setting than were Hispanic/Latino or Non-Hispanic POC respondents. Compared to English-language respondents, Spanish-language respondents reported more worry about hospitalization for both themselves (40.9% vs 86.8% very worried, p < .001) and others (64.8% vs 94.3% very worried, p = .002) and a greater likelihood of recommending mAb treatment to a family member or friend (42.6% vs 78.8% yes, p = .003). No other statistically significant differences by language of survey completion were found.  Participants recognized that answers to some of these questions might be particular to the individual. They expressed they would expect to have this conversation with a medical provider and wondered if medical providers were prepared to have these discussions. There were no notable differences in the type of information about benefits and risks across focus group participants' racial/ethnic or geographic characteristics. Participants had concerns about equitable access by racial/ethnic minority, medically fragile, low-income, immigrant, uninsured, and unhoused populations. (Quotes 14-16) Concerns about equitable access stemmed from the multi-step process to obtain mAbs that required access to medical care for diagnosis and referral, reliable transportation, and navigating a complex healthcare system where most information is available only in English. All focus groups expressed concern about the limited number of infusion centers outside of the Denver Metro areas and were pleased to learn of mobile treatment centers that had recently become available.
(Quote 18) Rural participants requested more specific information on the expected location of mobile treatment options. They expressed concern about accessing mobile treatment sites given long distances between incorporated areas, especially given the timeline for obtaining treatment might not coincide with when the mobile treatment site was close to their location. Spanishlanguage focus group discussions focused more on overcoming potential barriers to treatment access within the Latino immigrant community compared to English language focus groups' broader discussions of potential access disparities for multiple populations.
Costs associated with mAbs were of significant concern to focus group participants. Participants expressed that though the medication was free, there were other potential costs that could present a barrier to access for themselves or others. (Quotes 20, 21) Participants noted that insurance coverage for infusion costs could be hard to predict and that this could be an added stress to an already stressful situation when one was ill. (Quote 22) Discussions of cost also prompted discussion of equity as many people might not be able to afford the costs associated with mAb treatment and thus would not pursue it. (Quote 23) Cost discussions across focus group types were similar though Spanish-language focus groups did not dwell on this topic for long; participants acknowledged it as a significant barrier and then moved on to other topics.
Three priorities for mAb education and treatment emerged from the focus groups: 1) Spread the The priority to make it easy to obtain mAb treatment primarily focused on eliminating the requirement to get a provider referral for treatment. (Quotes 30-31) All focus group types felt this was critical to promoting equity and timely access to mAbs. Focus group participants also felt that more options for obtaining mAb treatment were needed, and some wondered if using injections rather than an infusion would expand access. (Quote 32) There were no differences across focus groups concerning the theme of "making it easy" to access mAbs. The theme, "Don't make it political," stemmed from concerns that information about the COVID-19 pandemic had been so polarizing. Participants reported that they did not believe mAbs was favored by one political party affiliation vs another. Results showed that community members thought the messaging should be shared in many locations and through multiple media based on varied media preferences by age, race/ethnicity and political affiliation. Focus group participants endorsed public communications campaigns despite acknowledging that messaging throughout the COVID-19 pandemic was problematic.
Participants also supported locally oriented and tailored messaging utilizing trusted community media, leaders, and healthcare providers. Participants recognized the challenges of implementing local messaging. For some, healthcare providers were a trusted source, but there was concern about healthcare providers having adequate knowledge of the treatment and the logistics of receiving it. Thus, a dissemination strategy is also needed to promote awareness among health care providers so they can be informed and proactive about educating and referring patients for treatment. Focus group participants shared a key concern about the challenges of implementing messaging at the local level and in a more personalized manner. From an equity perspective, community members expressed concern for those who lacked a trusted regular care provider or health insurance. Participants saw the role of other community leaders and organizations in spreading the word. They expressed the importance of having information on the treatment and how to access it connected to the COVID-19 testing process.
In addition to information dissemination, our findings support decreasing the logistical complexity of receiving mAb treatment. Focus group participants endorsed eliminating a required provider referral for treatment based on the time, costs and access barriers. This insight supported state-level policy eliminating the need for a referral, such as through a standing order for treatment [30]. While eliminating the provider referral could promote equity in the use of mAbs, it is plausible that it could widen disparities if mAb treatment access information is not equitably disseminated. Focus group participants supported broad dissemination but also emphasized that information campaign investments may need to be more targeted to communities that historically have less access to information and information that they feel applies to them. This suggests that information dissemination must be designed specifically to address current inequitable information access. Expanding access to treatment through treatment availability outside of "brick and mortar" infusion centers was highlighted as another strategy to decrease the logistical burden of mAb treatment. During focus groups, there was broad support for strategies like mobile treatment buses. However, survey respondents that were non-White had decreased willingness to receive mAb treatments in mobile care units. The reasons for this decreased willingness are unclear particularly concerning equitable access to and use of mAb treatment. The costs associated with mAb treatment was a key concern and may be quite complex to address in the US healthcare system. Focus group participants reported many ways people seeking mAb treatment could incur costs, from seeking care to obtaining the referral to bills for service from the infusion center. Based on their prior experiences with health care, they had little trust that the treatment would be affordable and worried about the financial impact on themselves and less financially secure community members.
Across the methods used in this study, trust was a key line of inquiry. Mistrust in the healthcare system has been identified as a factor in healthcare disparities, and increased trust has been associated with improved healthcare outcomes [31][32][33]. Compared to Hispanic/Latino and Non-Hispanic POC respondents, White Non-Hispanic respondents consistently reported greater trust in mAb safety and efficacy but, surprisingly, no differences in trust in availability or affordability. There were also no statistically significant racial/ethnic differences among survey respondents in their willingness to receive mAb treatment, although there were racial/ethnic differences in willingness to receive IV treatment in hospitals, specialty care centers, or mobile treatment sites. During focus groups, we noted comparatively less willingness to receive mAb treatment by Spanish-language and rural focus group participants. These participants expressed skepticism about the chemical components of the mAb treatment, side effects, and effectiveness of treatments. The skepticism expressed in Spanish-language focus groups may partly explain the data demonstrating that the state of Colorado had some of the widest disparities in COVID-19 vaccination between Latinos and Whites compared with other states [34]. In contrast, Spanish-language survey respondents expressed more trust in healthcare providers to provide a treatment recommendation. They were more likely to recommended mAbs to a family member or friend than English-language Hispanic language survey respondents. These findings likely indicate that multiple factors influence trust and that the impact of trust on health disparities among Latinos generally and among subgroups of the Latino population remains misunderstood.
A better understanding of how trust intersects with the COVID-19 disparities for Latinos could provide key insights into general health equity for this population. Finally, the frequent changes in messaging-necessitated by fluctuations in our understanding of the disease, treatment evidence, and accessible care-were seen as detrimental to earning community trust in public health communications.
The rapid evolution of evidence and changing circumstances are unfortunate but unavoidable pandemic phenomena, and communicating uncertainty is challenging, but mistrust in public health communication may have longstanding impacts. Despite focus group participant enthusiasm for broad dissemination campaigns, psychological research demonstrates that negative experiences often have a greater impact on subsequent behavior and emotions than positive ones. Thus the negativity bias towards COVID-19 communications may be difficult to overcome. [35]

Limitations
The denominator for the number of people eligible to participate and who were exposed to survey recruitment materials is unknown, and thus we cannot report a survey response rate.
Despite making the survey available in multiple languages, recruitment efforts did not reach those who spoke languages other than English or Spanish (except for one Amharic-speaking respondent). While partnerships with community organizations facilitated the representation of participants who were Hispanic/Latino at a rate higher than state demographics, we lacked partnerships with other important groups who also experience COVID-19 disparities, such as refugee communities from the Middle East, Africa, and Asia [36]. Thus, this study did not reveal their perspectives on mAb treatment for COVID-19. We also could not compare differences within other discrete racial groups represented in the broader POC category due to the small sample size.

Conclusion
Our findings indicate a critical need for better dissemination of general information about mAb treatment, especially among marginalized communities. Given the low levels of knowledge about mAbs we found across all survey demographics, there is a need for information dissemination to "everyone, everywhere". At the same time, given glaring disparities in COVID-19 infection, morbidity and mortality, the design of communication strategies must be rooted in promoting equity, which means making information available in varied community locations, multiple languages, appropriate for populations with varying degrees of literacy, and with clear guidance for those facing barriers to healthcare access. As the pandemic progresses, mAbs are no longer the first line treatment [37], but these priorities for information dissemination remain relevant. Equitable information dissemination alone, however, will not be sufficient to promote equity in access and use of treatments for COVID-19. Removing barriers related to who can prescribe or refer to treatment and increasing options for where people can access treatment will also play a key role. Finally, these findings underscore the need for broad stakeholder buy-in for generating solutions to public health issues in ways that are tailored to individual community perspectives, assets, and systems of communication and influence. For instance, involving community members and organizations that have a direct path to bring messages back to their constituents in a culturally responsive manner could be a way to build the infrastructure of information dissemination that would improve equity outcomes in the future.